Epigenetic Modification of MicroRNA-200b Contributes to Diabetic Vasculopathy
نویسندگان
چکیده
منابع مشابه
MicroRNA-200b Regulates Vascular Endothelial Growth Factor–Mediated Alterations in Diabetic Retinopathy
OBJECTIVE Diabetic retinopathy (DR) is a leading cause of blindness. Increased vascular endothelial growth factor (VEGF), promoting angiogenesis and increased permeability, is a key mechanistic abnormality in DR. We investigated microRNA (miRNA) alterations in DR with specific focus on miR-200b, and its downstream target, VEGF. RESEARCH DESIGN AND METHODS miRNA expression profiling microarray...
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BACKGROUND Diabetes mellitus is characterized by chronic vascular disorder and presents a main risk factor for cardiovascular mortality. In particular, hyperglycaemia and inflammatory cytokines induce vascular circulating tissue factor (TF) that promotes pro-thrombotic conditions in diabetes. It has recently become evident that alterations of the post-transcriptional regulation of TF via specif...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2017
ISSN: 1525-0016
DOI: 10.1016/j.ymthe.2017.09.009